One widely accepted view of the microprocessor revolution is that it will lead to massive unemployment, and the validity of this view is examined. Some of the predictions of job losses which may ensue are also considered, together with some of the possibilities for occupying increased leisure time which may result. The concept of «education for leisure» is examined vis a vis possible changes in employment patterns.

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side effects of steroids The Vent2 gene from Saccoglossus kowalevskii, a model hemichordate, successfully reprogrammed mammalian pre iPS cells to pluripotency, as demonstrated by the activation of dormant pluripotency genes, and the ability to generate all three primary germ layers.A second property of invertebrate Vents was also characterised in the Vent gene found in Nematostella vectensis, a sea anemone and model for cnidarian development, expression of which was insufficient to activate the endogenous pluripotency network of pre iPS cells, though it could induce the cells to a XEN like state that demonstrated up regulation of extra embryonic markers, and subsequently gained dependence on ERK signalling.A direct comparison between the Saccoglossus and Nematostella Vent homeodomains was used to provide insight into the step wise changes that appear to have given rise to Nanog activity. Swapping the homeodomains from one CDS to another, to create hybrid molecules, I demonstrated that the respective reprogramming activities of these genes is conserved in the homeodomain. I then identified specific amino acid (AAs) differences in the homeodomains that conferred a Nanog like capacity for reprogramming to the Nematostella gene.Identification of a Nematostella EsrrB ortholog, which demonstrated reprogramming activity in mammalian pre iPS cells, suggests wider conservation of pluripotency factors. side effects of steroids

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